The benefits associated with LDL-C–lowering statin-based therapies vary among patients with stroke owing to the different causes, and there are concerns that such a strategy may not be universally beneficial to all patients with ischemic stroke. 34 We found that more intensive LDL-C–lowering statin-based therapies were associated with a ...
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Confusion. Memory loss. Damage to your kidneys. Damage to your liver. Bad problems with your muscles. Type 2 diabetes or high blood sugar. Adults and teens can take statins. Most people don't have side effects from statins, but you shouldn't take them if you're pregnant, nursing or have certain types of liver disease.
Therefore, we performed the meta-analysis to explore the effect and safety of statin therapy after ICH. Methods: PubMed, EMbase and Cochrane Library were used to retrieve for clinical studies regarding the outcomes of statin therapy after ICH onset. The meta-analysis was performed by using RevMan 5.3 and stata12.0.
"NEXLIZET provides significant additional LDL-C lowering for adult patients with ASCVD or HeFH when added to maximally tolerated statin medicine, including those patients for whom maximally ...
In this cohort, the first statin prescription was simvastatin (84%), followed by atorvastatin for 14% . Another recent study conducted in Taiwan, using the Taiwan National health insurance database, also showed a significantly lower risk of all-cause mortality for statin-user (HR = 0.76;95% CI = 0.67–0.87, p < 0.001) .
Ren, Qing-wen and Tse, Yi-Kei and Li, Hang Long and Teng, Tiew-Hwa Katherine and Yu, Si-Yeung and Wu, Mei-zhen and Li, Xin-Li and Hung, Denise and Chen, Cong and Liu, Ming-ya and Tse, Hung-Fat Tse and Lam, Carolyn S.P. and Yiu, Kai-Hang, Statin is Associated with a Lower Risk of Incident Dementia in Heart Failure Patients: A …
Importance: The benefits and risks associated with intensive low-density lipoprotein cholesterol (LDL-C)-lowering statin-based therapies to lessen the risk of recurrent stroke have not been established. Objective: To conduct a meta-analysis of randomized clinical trials to evaluate the association of more intensive vs less intensive …
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Among adults with atherosclerotic CVD at very high risk, moderate-intensity statin plus ezetimibe combination therapy was noninferior to high-intensity statin …
Key Points. No, Nexlizet is not a statin medicine, but is used with a statin, diet and exercise to lower your cholesterol levels. Nexlizet contains two medicines, …
Using the data from 18 available publications, we examined the efficacy in treating or reducing the risk of MI by using random-effects models of odds ratio (OR) comparing the highest with the lowest category.Statins have demonstrated efficacy in treating or reducing the risk of MI (OR = 0.73, 95% confidence interval = 0.58-0.93, P = .010).This ...
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Statins (inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase) could effectively reduce the level of serum cholesterol. Statin therapy is effective for the primary prevention of vascular events in patients with DM. 9 One study indicated that statin therapy can reduce the rate of major vascular events in diabetic patients without diagnosed …
Statin therapy was associated with lower risk of WMH, lacunes, and EPVS progression than the non-statin therapy group after adjustment for confounders (all P < 0.05). There was no statistically significant difference in the risk of microbleeds between the statin and non-statin therapy groups (all, P > 0.05).
Our study found that adding ezetimibe to high-intensity statin therapy provided a significant but attenuated incremental reduction in LDL-C levels. Whether the magnitude of this …
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Zenith definition: The zenith of something is the time when it is most successful or powerful . | Meaning, pronunciation, translations and examples
Ezen, co-administered with an HMG-CoA reductase inhibitor (statin) is indicated as adjunctive therapy to diet for use in patients with primary (heterozygous …
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Using the data from 18 available publications, we examined the efficacy in treating or reducing the risk of MI by using random-effects models of odds ratio (OR) comparing the …
Lipid-altering agents encompass several classes of drugs that include hydroxymethylglutaryl (HMG) CoA reductase inhibitors or statins, fibric acid derivatives, bile acid sequestrants, cholesterol absorption inhibitors, and nicotinic acid. These drugs differ with respect to mechanism of action and to the degree and type of lipid lowering.
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Statin and ezetimibe combination therapy had beneficial effects on serum total cholesterol (weighted mean difference (WMD) -20.31 mg/dL, 95% confidence interval (CI), -26.87 to …
In controlled co-administration trials in patients receiving Ezen with a statin, consecutive transaminase elevations (> 3 X the upper limit of normal [ULN]) have been observed. When Ezen is co-administered with a statin, liver function tests should be performed at initiation of therapy and according to the recommendations of the statin.
Dosages. The bad Cognitive Effects: statins and memory loss (including reports of transient global amnesia), forgetfulness and confusion. Muscle pain: Coenzyme Q10 (ubiquinone) levels are …
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Purpose: To evaluate the association of prior to intensive care unit (ICU) statin use with the clinical outcomes in critically ill patients with acute kidney injury (AKI).Materials and Methods: Patients with AKI were selected from the Medical Information Mart for Intensive Care IV (version 1.0) database for this retrospective observational …
Compared with the non-statin group, the statin group was older, more likely to have comorbidities but with a lower level of inflammatory markers. The Statin group also had a lower adjusted mortality risk (6.44% vs. 10.88%; adjusted hazard ratio [HR] 0.47; 95% CI, 0.29-0.77). Subgroup analysis of CHD patients showed a similar result.
Statin medications are used in the management and treatment of hypercholesteremia. They are known to be inhibitors of the hydroxymethylglutaryl-CoA reductase enzyme and lower total cholesterol, low-density lipoprotein (LDL), and triglyceride concentrations while increasing high-density lipoprotein (HDL) concentrations. FDA …
Purpose: To confirm that statin use can reduce the risk of post-stroke seizures (PSS), and to further investigate the association between the details of specific statin therapy, including the initial time, types, doses, courses, and the risk of PSS. Methods: Patients with newly-onset ischemic stroke and no history of epilepsy before stroke were enrolled.